Research news
This page features recent published research on Coeliac and Small Intestinal Diseases, that we believe is informative to the field.
European Guideline for Coeliac Disease
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Our new guideline has been published!
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Part 1Â focuses on establishing the coeliac diagnosis and includes the serology-only approach.
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Part 2 focuses on the management of CeD following a confirmed diagnosis. It outlines dietary approaches for therapy, protocols for long-term monitoring, and the management of patients who exhibit complicative courses.
IL-2 in whole blood for Celiac diagnosis
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Published in June 2025 in Gastroenterology, Jason Tye-Din´s group from Melbourne, Australia, have provided prospectively collected data on a new assay measuring IL-2 in whole blood (so-called WBAIL-2 assay). They show sensitivities up to 90% and specifities as high as 95% even in patients already consuming a gluten-free diet.
Moscatelli et al., doi: 10.1053/j.gastro.2025.05.022.
IFN-gamma causes crypt hyperplasia
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Jorunn Stamnaes, PI in Ludvig Sollid´s group in Oslo, has convincingly shown in human small intestinal tissue and also in a murine conditional knock-out model, that T-cell derived IFN-gamma will trigger crypt hyperplasia by signaling in epithelia via the IFNg-receptor-1/STAT1 axis.
Stamnaes et al., doi.org/10.1172/JCI194858.
